What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of acetaminophen and oxycodone can be fatal. While taking oxycodone with acetaminophen, do not take nonprescription acetaminophen or other medicines that contain acetaminophen, including many cold medicines.Adults should not take more than 3,000 to 4,000 mg of acetaminophen each Percocet contains oxycodone and acetaminophen. Oxycodone is an opiate painkiller. Acetaminophen reduces pain and fever. Both of these drugs can play important medical roles. Both of these drugs can be dangerous in large quantities. Percocet can cause overdose. Managing health involves finding a Oxycodone & Acetaminophen Overdose Back to Top If you take too much oxycodone/acetaminophen, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away. An overdose of Percocet 5/325 can be fatal. The first signs of an acetaminophen overdose include loss of appetite, nausea , vomiting , stomach pain, sweating, and confusion or weakness. Later symptoms may include pain in your upper stomach, dark urine, and yellowing of your skin or the whites of your eyes. Accidental ingestion of oxycodone hydrochloride and acetaminophen oral solution, especially by children, can result in respiratory depression and death due to an overdose of oxycodone hydrochloride and acetaminophen oral solution. The blend of the opioid oxycodone and acetaminophen in Percocet makes this a unique drug—with overdose symptoms and side effects that truly set it apart. Oxycodone/acetaminophen has a risk for abuse and addiction, which can lead to overdose and death. Oxycodone/acetaminophen may also cause severe, possibly fatal, breathing problems. To lower your. Drug Information on Endocet, Endocet 10/325, Endocet 2.5/325 (acetaminophen and oxycodone) includes drug pictures, side effects, drug interactions, directions for use, symptoms of overdose, and what to avoid. The combination oxycodone/paracetamol (North American trade name Percocet, generic Endocet and Ratio-Oxycocet in Canada) is a combined opioid/non-opioid pain reliever used to treat moderate to severe acute (short-term) pain, marketed by Endo International plc, formerly Endo Pharmaceuticals.